<html>
<head>
<style>
p:first-letter {
  position: relative;
  left:100px;
  top:100px;
  font-size: 24px;
  color:red;
}
</style>
</head>
<body>
<p>
A The "A" should be big and red and ignore the position: relative.
</p>
</body>
</html>